Fundamentals and application of electrocardiology. Ion channel. Ion channel of myocardial cells.

Ion channel activity drives ion channel expression.

Acid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs

Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...

Effect of crude Venom of Odonthobuthus doriae scorpion in cell culture using ion channel modulators

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...

Effect of crude Venom of Odonthobuthus doriae scorpion in cell culture using ion channel modulators

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...

Ion permeation through neuronal nAChR ion channel

Alzheimer’s dementia is related to loss of inter-neuron communication by nicotinic acetylcholine receptors (nAChR) at post synaptic neurons, and successful therapy approaches rely e.g. on modulations of response signals initiated by ion flux through the receptor integrated ion channel. We have evaluated Umbrella Sampling (US) and Steered Molecular Dynamics (SMD) pulling for calculation of the p...